How to Use major depressive disorder in a Sentence

major depressive disorder

noun
  • It is designed for adults 18 and older with moderate to severe major depressive disorder.
    — Kurt Knutsson, FOXNews.com, 20 Jan. 2026
  • Some research suggests that omega-3 supplements may improve mood for people with major depressive disorder.
    — Sarah Garone, Health, 30 Jan. 2026
  • The drug is approved for the treatment of schizophrenia and bipolar depression, and in November, its label was expanded to treat major depressive disorder.
    — Jeff Marks, CNBC, 8 Apr. 2026
  • Thames admitted that the diagnosis had never been formally made before, with prior records listing major depressive disorder.
    — Amber Corrine, VIBE.com, 26 Sep. 2025
  • Consumption of soft drinks may be linked to a diagnosis of major depressive disorder (MDD), along with more severe symptoms, most notably in women, a study has found.
    — Hannah Millington, MSNBC Newsweek, 30 Sep. 2025
  • Zeko’s predicament fit what experts call treatment-resistant depression, which isn’t a formal diagnosis separate from major depressive disorder.
    — Cnn.com Wire Service, Mercury News, 15 Jan. 2026
  • One of them still lives at home and has been diagnosed with autism, ADHD, PTSD and major depressive disorder.
    — Jeanne Phillips, Dallas Morning News, 10 Feb. 2026
  • While feeling sad after a disappointment or a loss is a normal part of being human, clinical depression, formally known as major depressive disorder, is a medical condition.
    — Daryl Austin, USA Today, 14 Mar. 2026
  • One of our children still lives with me and has been diagnosed with autism, ADHD, PTSD and major depressive disorder.
    — Jeanne Phillips, Mercury News, 10 Feb. 2026
  • Antipsychotics Antipsychotics are medications used to treat serious mental health conditions like major depressive disorder and schizophrenia.
    — Carrie Madormo, Verywell Health, 19 Aug. 2025
  • Antipsychotics Antipsychotics are medications used to treat serious mental health conditions like major depressive disorder and schizophrenia.
    — Carrie Madormo, Verywell Health, 7 Jan. 2026
  • People with anxiety and mood disorders, including bipolar disorder and major depressive disorder, may periodically have symptoms that interfere with their ability to do their jobs.
    — Emily Rosado-Solomon, The Conversation, 15 Dec. 2025
  • Treatment of a serious mental illness that can lead to suicide, such as major depressive disorder, often centers on medication and talk therapy with little or no consideration of factors such as social isolation or financial duress.
    — Aneri Pattani, USA Today, 6 June 2026
  • As just one example, two people receiving a diagnosis of major depressive disorder may have very different underlying biological mechanisms driving their illness, and very different responses to the same treatment.
    — Eric J. Nestler, STAT, 28 Apr. 2026
  • In August, for instance, pharmaceutical giant AbbVie inked a billion-dollar deal, the first of its kind, to acquire Bretisilocin, a psychedelic compound used to treat major depressive disorder.
    — Jerel Ezell, STAT, 1 May 2026
  • Reduced dopamine activity is commonly seen in people suffering from major depressive disorder, particularly in cases involving anhedonia, a condition marked by the inability to feel pleasure even when mood symptoms improve.
    — Kaif Shaikh, Interesting Engineering, 18 Aug. 2025
  • The companies are studying psilocybin for treatment-resistant depression and major depressive disorder and methylone for post-traumatic stress disorder (PTSD).
    — Mary Kekatos, ABC News, 24 Apr. 2026
  • Under cross-examination, Thames admitted that diagnosis had never been formally made before, and that LeMaistre’s previous records listed major depressive disorder instead.
    — Amber Corrine, VIBE.com, 25 Sep. 2025
  • This is critically important because most existing treatments for psychiatric conditions (including major depressive disorder and schizophrenia) involve a significant delay in efficacy.
    — Eric J. Nestler, STAT, 28 Apr. 2026
  • The initiative, dubbed the Party Line project, is the brainchild of Matter Neuroscience, a mental health startup focused on researching the science behind happiness and creating tools to battle major depressive disorders.
    — Clara Harter, Los Angeles Times, 23 Jan. 2026
  • Conditions such as major depressive disorder, bipolar disorder, post-traumatic stress disorder, schizophrenia and severe anxiety disorders frequently involve fluctuating symptoms.
    — Jeffrey Freedman, Sun Sentinel, 27 Apr. 2026
  • In 2021, 1 in 5 students experienced major depressive disorder, according to the National Survey of Drug Use and Health.
    — Lexi Lonas Cochran, The Hill, 22 Aug. 2025
  • Researchers are working hard to find non-invasive, drug-free ways to treat conditions such as ADHD and major depressive disorder (MDD), and there have been a lot of promising studies on experimental therapies.
    — New Atlas, 21 Jan. 2026
  • The trials covered seven therapeutic areas where researchers had previously documented seeding trials, including major depressive disorder, epilepsy, Type 2 diabetes and rheumatoid arthritis.
    — Sukhun Kang, The Conversation, 6 May 2026
  • Specifically, the companies are investigating psilocybin as a therapy for treatment-resistant depression and for major depressive disorder; methylone is being studied as a potential treatment for PTSD.
    — Claire Cameron, Scientific American, 24 Apr. 2026
  • News, Jace was diagnosed with several mental health disorders, including ADHD, major depressive disorder and oppositional defiant disorder.
    — Julia Moore, PEOPLE, 14 Oct. 2025
  • News, Jenelle has previously disclosed that Jace was diagnosed with several mental health disorders, including ADHD, major depressive disorder and ODD.
    — Angela Andaloro, People.com, 28 Aug. 2025
  • However, it was subsequently discovered that Phillips had previously been diagnosed with psychosis, paranoia and major depressive disorder at John Peter Smith Hospital, according to Denton County sheriff’s records.
    — Matthew Adams, Fort Worth Star-Telegram, 7 Nov. 2025
  • Priority review vouchers will go to Compass’ psilocybin product for treatment-resistant depression, Usona’s similar medicine for major depressive disorder, and an MDMA-like treatment for post-traumatic stress disorder from Transcend.
    — Theresa Gaffney, STAT, 27 Apr. 2026
  • The agency will grant priority review vouchers specifically to Compass’ psilocybin product for treatment-resistant depression, Usona’s similar medicine for major depressive disorder, and an MDMA-like treatment for post-traumatic stress disorder from Transcend.
    — Elaine Chen, STAT, 24 Apr. 2026

Some of these examples are programmatically compiled from various online sources to illustrate current usage of the word 'major depressive disorder.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

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